Year : 2019 | Volume
: 22 | Issue : 1 | Page : 54--58
Effect of pretreatment medication on postendodontic pain: A double-blind, placebo-controlled study
Ravi Kumar Konagala, Jyothi Mandava, Ravi Kumar Pabbati, A Anupreeta, Roopesh Borugadda, Ravichandra Ravi
Department of Conservative Dentistry and Endodontics, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India
Background: Posttreatment endodontic pain has been reported in 25%–40% of all endodontic patients. Effective management of endodontic pain represents a continuing challenge.
Aim: To evaluate and compare the efficacy of preoperative single dose of nonsteroidal anti-inflammatory drug, piroxicam (20 mg), with two types of corticosteroid drugs – dexamethasone (4 mg) or deflazacort (30 mg) – for the prevention and control of postendodontic pain.
Materials and Methods: A total of 132 volunteers selected for nonsurgical root canal therapy were randomly divided into the following four groups (n = 30 each) according to preoperative medication given: Group 1, piroxicam (20 mg); Group 2, dexamethasone (4 mg); Group 3, deflazacort (30 mg); and Group 4, placebo. The preoperative medications were administrated 1 h before the start of standard endodontic treatment. Patients were instructed to complete a pain diary using Visual Analog Scale preoperatively and at 6-, 12-, 24-, 48-, and 72-h intervals after root canal instrumentation.
Statistical Analysis: The correlation between preoperative endodontic pain to postoperative pain and pair-wise comparison of four groups was evaluated by Kruskal–Wallis analysis of variance test followed by Mann–Whitney U-test.
Results: Compared to the placebo group, piroxicam, dexamethasone, and deflazacort resulted in a statistically significant reduction in postendodontic pain at 6, 12, and 24 h (P < 0.05).
Conclusion: Preoperative single oral dose of piroxicam or dexamethasone or deflazacort is equally effective in controlling postendodontic pain.
Dr. Jyothi Mandava
GITAM Dental College and Hospital, Rushikonda, Visakhapatnam - 530 045, Andhra Pradesh
|How to cite this article:|
Konagala RK, Mandava J, Pabbati RK, Anupreeta A, Borugadda R, Ravi R. Effect of pretreatment medication on postendodontic pain: A double-blind, placebo-controlled study.J Conserv Dent 2019;22:54-58
|How to cite this URL:|
Konagala RK, Mandava J, Pabbati RK, Anupreeta A, Borugadda R, Ravi R. Effect of pretreatment medication on postendodontic pain: A double-blind, placebo-controlled study. J Conserv Dent [serial online] 2019 [cited 2022 May 22 ];22:54-58
Available from: https://www.jcd.org.in/article.asp?issn=0972-0707;year=2019;volume=22;issue=1;spage=54;epage=58;aulast=Konagala;type=0