| ORIGINAL ARTICLE |
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| Year : 2021 | Volume
: 24
| Issue : 1 | Page : 24-28 |
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The additive effect of clonidine to lidocaine on postoperative pain management after root canal treatment on mandibular molars with symptomatic irreversible pulpitis: A prospective randomised double-blind clinical trial
Elham Shadmehr1, Nima D Sarmast2, Amin Davoudi3, Yoo J Chung1, Howard H Wang4
1 Department of Preventive and Restorative Dental Science, School of Dentistry, University of California, San Francisco, CA, USA
2 Department of Periodontics and Dental Hygiene, School of Dentistry at Houston, University of Texas, Houston, TX, USA
3 Torabinejad Dental Research Center, Isfahan, Iran
4 Department of Dental Medicine, New York Medical College, Valhalla, NY, USA
Correspondence Address:
Dr. Elham Shadmehr
707 Parnassus Avenue, D3214, San Francisco, CA 94143-0758
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/JCD.JCD_523_20
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Context: Postoperative pain control has been a common challenge to clinicians in endodontics.
Aims: This double-blind randomized clinical trial assessed the efficacy of clonidine added to lidocaine for postoperative pain following endodontic treatment of mandibular molars with symptomatic irreversible pulpitis (SIP).
Methods: One hundred participants with lower molars experiencing SIP were recruited and randomly assigned to two groups. 1.8 mL of 2% lidocaine with either epinephrine (1:80,000) or clonidine (15 μg/mL) was administered to each group via an inferior alveolar nerve block. A Heft–Parker Visual Analog Scale was used to rate preoperative pain and at 6, 12, 24, 36, 48, and 72 h following endodontic treatment. Their postoperative analgesic consumption was recorded.
Statistical Analysis Used: The analgesic efficacy was analyzed by Chi-square test, paired t-test, and repeated measures ANOVA (P < 0.05).
Results: Early postoperative pain was significantly lower in the lidocaine/clonidine group than the lidocaine/epinephrine group (6 h: P = 0.038; 12 h: P = 0.031). The lidocaine/clonidine group consumed a significantly lower amount of analgesics (P = 0.048).
Conclusions: The administration of clonidine added to lidocaine may reduce early postoperative pain and consumption of analgesics following endodontic treatment in lower molars with SIP.
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