Journal of Conservative Dentistry
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Year : 2021  |  Volume : 24  |  Issue : 1  |  Page : 24-28

The additive effect of clonidine to lidocaine on postoperative pain management after root canal treatment on mandibular molars with symptomatic irreversible pulpitis: A prospective randomised double-blind clinical trial

1 Department of Preventive and Restorative Dental Science, School of Dentistry, University of California, San Francisco, CA, USA
2 Department of Periodontics and Dental Hygiene, School of Dentistry at Houston, University of Texas, Houston, TX, USA
3 Torabinejad Dental Research Center, Isfahan, Iran
4 Department of Dental Medicine, New York Medical College, Valhalla, NY, USA

Correspondence Address:
Dr. Elham Shadmehr
707 Parnassus Avenue, D3214, San Francisco, CA 94143-0758
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCD.JCD_523_20

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Context: Postoperative pain control has been a common challenge to clinicians in endodontics. Aims: This double-blind randomized clinical trial assessed the efficacy of clonidine added to lidocaine for postoperative pain following endodontic treatment of mandibular molars with symptomatic irreversible pulpitis (SIP). Methods: One hundred participants with lower molars experiencing SIP were recruited and randomly assigned to two groups. 1.8 mL of 2% lidocaine with either epinephrine (1:80,000) or clonidine (15 μg/mL) was administered to each group via an inferior alveolar nerve block. A Heft–Parker Visual Analog Scale was used to rate preoperative pain and at 6, 12, 24, 36, 48, and 72 h following endodontic treatment. Their postoperative analgesic consumption was recorded. Statistical Analysis Used: The analgesic efficacy was analyzed by Chi-square test, paired t-test, and repeated measures ANOVA (P < 0.05). Results: Early postoperative pain was significantly lower in the lidocaine/clonidine group than the lidocaine/epinephrine group (6 h: P = 0.038; 12 h: P = 0.031). The lidocaine/clonidine group consumed a significantly lower amount of analgesics (P = 0.048). Conclusions: The administration of clonidine added to lidocaine may reduce early postoperative pain and consumption of analgesics following endodontic treatment in lower molars with SIP.

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