| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 23
| Issue : 1 | Page : 46-50 |
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Comparative evaluation of substantivity of two biguanides - 0.2% polyhexanide and 2% chlorhexidine on human dentin
Rita Chandki1, Vineeta Nikhil2, S Sai Kalyan3
1 Swami Vivekanand Subharti University, Meerut, Uttarpradesh, India
2 Department of Conservative Dentistry and Endodontics, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India
3 Department of Conservative Dentistry and Endodontics, Rural Dental College, Loni, Maharashtra, India
Correspondence Address:
Dr. Rita Chandki
12.A Vaishali Nagar, Indore - 452 009, Madhya Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/JCD.JCD_256_19
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Background: Substantivity is one of the desirable characteristics of root canal irrigants. Among conventional endodontic irrigants, only chlorhexidine (CHX) is known to exert significant substantivity on root canal dentin. This study explored the substantivity activity of a polymeric biguanide-poly hexamethylene biguanide (PHMB).
Aim: The aim of this study was to determine the substantivity of a polymeric biguanide - 0.2% PHMB and compare it with that of 2% CHX.
Materials and Methods: To evaluate and compare the substantivity of 0.2% PHMB and 2% CHX on root canal dentin, dentin disks were prepared and substantivity after 1 h, 24 h, 7 days and 21 days was measured using spectrophotometry.
Statistical Analysis Used: The data so obtained were analyzed, and the intergroup comparison was made using unpaired t-test.
Results: The results of this study indicated that 0.2%. PHMB exerts significantly greater substantivity than 2% CHX on human dentin.
Conclusion: Within the limitations, this study supports the use of 0.2% polyhexanide as an endodontic irrigant based on its property of substantivity.
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