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Effect of two desensitizing agents on dentin hypersensitivity: A randomized split-mouth clinical trial
Angambakkam Rajasekaran PradeepKumar1, Venkatnagaraj Viswanath1, Kamna Singh2, Kuzhanchinathan Manigandan3, Haseena Begum Iqbal4, Anil Kishen5
1 Department of Conservative Dentistry and Endodontics, Thai Moogambigai Dental College and Hospital, Dr. MGR Educational and Research Institute (Deemed to be University) Chennai, India
2 Dental Research Institute, Faculty of Dentistry, 124 Edward Street, Toronto, Canada
3 Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, Tamilnadu, India
4 Dental Clinic, Chennai, Tamilnadu, India
5 Dental Research Institute, Faculty of Dentistry, 124 Edward Street; Department of Dentistry, Mount Sinai Hospital, Sinai Health System, Toronto, Canada
Correspondence Address:
Dr. Angambakkam Rajasekaran PradeepKumar
Department of Conservative Dentistry and Endodontics, Thai Moogambigai Dental College and Hospital, Dr. MGR Educational and Research Institute (Deemed to be University), Chennai - 600 095, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/JCD.JCD_22_20
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Background: Clinical research is important to evaluate the effect of desensitizing agents.
Aims: This randomized clinical trial evaluated the immediate and 1 week desensitizing effect of two desensitizing agents Uno Topical Gel and Profluorid.
Materials and Methods: Thirtyfive patients with teeth presenting with dentin hypersensitivity were included in this clinical trial. Each quadrant in a patient was randomly assigned to one of two groups: Uno Topical Gel or Profluorid Varnish. A VAS score was used to assess tooth sensitivity at baseline, immediately after application of desensitizer and after 1 week. Additionally, 30 dentin discs were prepared, divided into Group 1(Control Group), Group 2 (Profluorid Varnish) and Group 3 (Uno Topical Gel) and examined using scanning electron microscopy (SEM) after 1hour and 24 hours to evaluate tubule occlusion.
Statistical Analysis: Clinical data were analysed using Friedman's test and Mann – Whitney U test. SEM data was analysed using Student's 2-sample t-test.
Results: Uno group was significantly better to evaporative stimuli immediately (P=0.01) after application. After 1 week, Uno group was significantly better to tactile (P=0.000) and evaporative (P=0.000) stimuli than Profluorid. SEM images showed that 1 hour after application, Uno and Profluorid demonstrated more than 90% and 80% dentin tubule occlusion respectively. At 24 hours, Uno and Profluorid demonstrated more than 50% and 60% dentin tubule occlusion respectively.
Conclusions: Uno Topical Gel was significantly better than Profluorid in reducing pain of dentin hypersensitivity due to tactile and evaporative stimuli after 1 week.
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